Azetidine → 1-[(5-Bromo-2-thienyl)methyl]azetidine

HRID 387381노트

반응식

HRID 387381 반응식
[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]C2)=[CH:4][CH:3]=1.N1CCC1>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 10422AzetidineHCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

생성물 1

HCID 593327501-[(5-Bromo-2-thienyl)methyl]azetidine

실험 절차

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using azetidine (86 mg, 1.5 mmol) as the amine. Following the purification with the SCX column as described -[(5-bromo-2-thienyl)methyl]pyrrolidine an additional purification step on a 40 g ISCO silica column was necessary to afford the title compound (166 mg) of acceptable purity for use in the next reaction.

후처리

  1. customthe purification with the SCX column
  2. customan additional purification step on a 40 g ISCO silica column

출처 및 근거

ORD 기록
ord-23eca20410af448b92c0fb964823589f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372875B2

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