Benzyl azide → 4-(1-benzyl-1H-1,2,3-triazol-5-yl)benzaldehyde

HRID 387405

반응식

HRID 387405 반응식
[CH2:1]([N:8]=[N+:9]=[N-:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:11]([C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=1)#[CH:12]>C[C-]1C(C)=C(C)C(C)=C1C.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Ru+].C1C=CC=CC=1>[CH2:1]([N:8]1[C:11]([C:13]2[CH:20]=[CH:19][C:16]([CH:17]=[O:18])=[CH:15][CH:14]=2)=[CH:12][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 12152Benzyl azideHCID 27716454-Ethynylbenzaldehyde

생성물 1

HCID 116805234-(1-benzyl-1H-1,2,3-triazol-5-yl)benzaldehyde

시약·촉매·용매 2

HCID 71310463Chlororuthenium(1+) 1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-ide--triphenylphosphane (1/1/2)촉매HCID 241Benzene용매

실험 절차

Benzyl azide (0.200 g, 1.50 mmol), 4-ethynylbenzaldehyde (0.200 g, 1.54 mmol), Cp*RuCl(PPh3)2 (25 mg, 0.031 mmol). Solvent, benzene; reaction temperature, 80° C.; reaction time, 2 hours; yield, 0.32 g (81%). EI-MS: m/z 264 [M+1].

후처리

  1. customreaction temperature, 80° C.
  2. customreaction time, 2 hours
  3. customyield

출처 및 근거

ORD 기록
ord-f8cb6781f79b4e22a85b531c4ad50dd2
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372986B2

연결된 노트

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