Diisopropylethylamine → N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)-N'-(3-methylisoxazol-5-yl)urea

HRID 387754노트

반응식

HRID 387754 반응식
[NH2:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[C:14]([C:17]#[N:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[CH3:26][C:27]1[CH:31]=[C:30]([NH:32][C:33](=O)[O:34]C2C=CC=CC=2)[O:29][N:28]=1.C(N(C(C)C)CC)(C)C>C1(C)C=CC=CC=1>[C:17]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][C:13]=1[O:19][CH2:20][CH2:21][O:22][CH3:23])[N:10]=[CH:9][CH:8]=[C:7]2[O:6][C:5]1[CH:4]=[CH:3][C:2]([NH:1][C:33]([NH:32][C:30]2[O:29][N:28]=[C:27]([CH3:26])[CH:31]=2)=[O:34])=[CH:25][CH:24]=1)#[N:18]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 229365064-(4-Aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinolineHCID 22936635Phenyl (3-methylisoxazol-5-yl)carbamate

생성물 1

HCID 22936702N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxyphenyl)-N'-(3-methylisoxazol-5-yl)urea수율 74.5%

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
100 °C

실험 절차

The 4-(4-aminophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (100 mg) synthesized in Production Example 10 and phenyl N-(3-methylisoxazol-5-yl)carbamate (81 mg) were added to toluene (5 ml), diisopropylethylamine (0.88 ml) was added and the mixture was heated and stirred at 100° C. for 2 hours. After cooling, the precipitated crystals were filtered and washed with an ethyl acetate:toluene (1:1) mixed solvent to obtain the title compound (102 mg).

후처리

  1. additionwas added
  2. temperaturethe mixture was heated
  3. temperatureAfter cooling
  4. filtrationthe precipitated crystals were filtered
  5. washwashed with an ethyl acetate:toluene (1:1)
  6. additionmixed solvent

출처 및 근거

ORD 기록
ord-f4b10c5322fc41718a0334dc3943400a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372981B2

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