8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione → 8-(2-Methoxy-4-cyano-phenyl)-1H,3H-purin-2,6-dione

HRID 3878노트

반응식

HRID 3878 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1>P(Cl)(Cl)(Cl)=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:11])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1

참가 물질

3

반응물 1

HCID 201532438-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

생성물 1

HCID 201532568-(2-Methoxy-4-cyano-phenyl)-1H,3H-purin-2,6-dione

시약·촉매·용매 1

HCID 24813Phosphorus oxychloride용매

실험 절차

Prepared by boiling 0.7 gm of 8-(2-methoxy-4-aminocarbonylphenyl)-1H,3H-purin-2,6-dione in 10 ml of phosphorus oxychloride for 24 hours. The compound crystallizes as the hemihydrate.

후처리

  1. customPrepared
  2. customfor 24 hours
  3. customThe compound crystallizes as the hemihydrate

출처 및 근거

ORD 기록
ord-659dfef79a1345f9a27aa0d9cf9068c9
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722929

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