1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 388238

반응식

HRID 388238 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH2:18][CH2:17]1

참가 물질

5

반응물 2

HCID 531671-MethylpiperazineHCID 949542-Fluoro-5-nitrobenzotrifluoride

생성물 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

2-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at rt overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

후처리

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

출처 및 근거

ORD 기록
ord-8e10d5100d4a4836a4774419c19704fe
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377924B2

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