Hydrazine hydrate (1:1) → 2,2-Diphenylacetohydrazide

HRID 388258

반응식

HRID 388258 반응식
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8](OC)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:19][NH2:20]>CCO>[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]([NH:19][NH2:20])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 77019Methyl alpha-phenylbenzeneacetate

생성물 1

HCID 2261392,2-Diphenylacetohydrazide수율 97%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of methyl 2,2-diphenylacetate (0.5 g, 1 equiv) in anhydrous EtOH (150 mL) was added hydrazine hydrate (8 mL) and heated to reflux. Stirring was then continued for 1 hour. The reaction mixture was then cooled and the solvents removed under reduced pressure. The crude oil was diluted with EtOAc and washed with H2O and the organic phase dried over Na2SO4, filtered, and the solvents removed under reduced pressure to yield a yellow oil (0.97 g, 97%) that was used without further purification.

후처리

  1. temperatureheated to reflux
  2. temperatureThe reaction mixture was then cooled
  3. customthe solvents removed under reduced pressure
  4. additionThe crude oil was diluted with EtOAc
  5. washwashed with H2O
  6. dry with materialthe organic phase dried over Na2SO4
  7. filtrationfiltered
  8. customthe solvents removed under reduced pressure

출처 및 근거

ORD 기록
ord-245f2a0a060f4062b6cc4b5c7f07d2ec
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377930B2

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