Hydrazine hydrate (1:1) → 3-Methyl-2-phenylbutanehydrazide

HRID 388269노트

반응식

HRID 388269 반응식
[CH3:1][CH:2]([CH3:14])[CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4](OC)=[O:5].O.[NH2:16][NH2:17]>>[CH3:1][CH:2]([CH3:14])[CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([NH:16][NH2:17])=[O:5]

참가 물질

3

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 5051294Methyl 3-methyl-2-phenylbutanoate

생성물 1

HCID 591858993-Methyl-2-phenylbutanehydrazide수율 47%

실험 절차

A stirred solution of methyl 3-methyl-2-phenylbutanoate (0.87 g, 1 eq) and hydrazine hydrate (10 mL) was heated at 110° C. for 12 h. The reaction mixture was then cooled and the solvents removed under reduced pressure. The crude oil was diluted with EtOAc and washed with H2O and the organic phase dried over Na2SO4, filtered, and the solvents removed under reduced pressure to yield a yellow oil (0.17 g, 47%) that was purified by column chromatography over silica gel to yield the product (0.61 g).

후처리

  1. temperatureThe reaction mixture was then cooled
  2. customthe solvents removed under reduced pressure
  3. additionThe crude oil was diluted with EtOAc
  4. washwashed with H2O
  5. dry with materialthe organic phase dried over Na2SO4
  6. filtrationfiltered
  7. customthe solvents removed under reduced pressure

출처 및 근거

ORD 기록
ord-5f8a95886bd140b7b291494a4efa12d1
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377930B2

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