Hydroxyamine hydrochloride → 4-Fluoro-naphthalene-1-carbaldehyde oxime

HRID 388375노트

반응식

HRID 388375 반응식
C([O-])(=O)C.[Na+].Cl.[NH2:7][OH:8].[F:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=O)=[CH:12][CH:11]=1>C1COCC1.O>[F:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=[N:7][OH:8])=[CH:12][CH:11]=1

참가 물질

6

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 70225244-Fluoronaphthalene-1-carbaldehyde

생성물 1

HCID 866581594-Fluoro-naphthalene-1-carbaldehyde oxime

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Sodium acetate (4.8 g) is added to a solution of hydroxylamine hydrochloride (2.9 g) and 4-fluoro-naphthalene-1-carbaldehyde (8.1 g, example 1 step B) in THF (40 ml) and water (10 ml). After 3 hours at room temperature, the reaction is quenched with water and ethyl acetate. The organic, phase is separated and the water phase is extracted with ethyl acetate. The combined organic phases are washed with water and with a saturated aqueous solution of NaCl, dried over Mg2SO4 and concentrated in vacuo to yield 4-fluoro-naphthalene-1-carbaldehyde oxime. The crude product obtained is used without further purification.

후처리

  1. customthe reaction is quenched with water and ethyl acetate
  2. customThe organic, phase is separated
  3. extractionthe water phase is extracted with ethyl acetate
  4. washThe combined organic phases are washed with water and with a saturated aqueous solution of NaCl
  5. dry with materialdried over Mg2SO4
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-3b266ea26e3643ad97a7c9fef3778853
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377942B2

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