Hydrochloric Acid → 4,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid

HRID 388463노트

반응식

HRID 388463 반응식
[CH3:1][C:2]1[C:7]2[C:8]([C:11](N)=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1.[OH-:15].[K+].Cl>CCO.O>[CH3:1][C:2]1[C:7]2[C:8]([C:11]([OH:15])=[O:12])=[N:9][S:10][C:6]=2[CH:5]=[C:4]([CH3:14])[CH:3]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 584974364,6-Dimethyl-1,2-benzisothiazole-3-carboxylic acid amide

생성물 1

HCID 584973864,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid수율 75%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
85 °C

실험 절차

To a solution of 4,6-dimethyl-1,2-benzisothiazole-3-carboxylic acid amide (20 mg, 0.097 mmol) in EtOH (10 mL) and H2O (2 mL) is added KOH (11′mg, 0.19 mmol). The solution is heated to 85° C. for 48 hours. The solution is cooled down and is placed in an ice bath. Conc. HCl is added to adjust the pH of the solution to 2. The precipitated solid is collected by means of filtration to afford 4,6-Dimethyl-1,2-benzisothiazole-3-carboxylic acid (15 mg, 75%).

후처리

  1. temperatureThe solution is cooled down
  2. customis placed in an ice bath
  3. filtrationThe precipitated solid is collected by means of filtration

출처 및 근거

ORD 기록
ord-571a284335fc43bc8eb820b22c57a297
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377949B2

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