Benzoyl isothiocyanate → 1-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

HRID 3889

반응식

HRID 3889 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:4][CH2:3]1.[C:19]([N:27]=[C:28]=[S:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C=CC=CC=1>[C:19]([NH:27][C:28]([NH:1][CH:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[CH:10]=2)[CH2:6][CH2:7]1)=[S:29])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 2

HCID 68284Benzoyl isothiocyanateHCID 111958234-Amino-1-(2-naphthyl)methylpiperidine

생성물 1

HCID 129423461-Benzoyl-3-[1-(naphth-2-ylmethyl)piperid-4-yl]thiourea

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

4-Amino-1-(naphth-2-ylmethyl)piperidine (1.0 g, 0.0042 m) and benzoylisothiocyanate (0.69 g, 0.0042 m) in toluene (120 cm3) was stirred at room temperature for 6 hours. The solvent was evaporated and the gum dissolved in isopropyl alcohol and acidified with ethanolic HCl. The solvent was evaporated and the residue dissolved in ethyl acetate. The title compound crystallised and was filtered and dried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe gum dissolved in isopropyl alcohol
  3. customThe solvent was evaporated
  4. dissolutionthe residue dissolved in ethyl acetate
  5. customThe title compound crystallised
  6. filtrationwas filtered
  7. dry with materialdried as the monohydrochloride quarterhydrate salt, m.p. 212°-214° C.

출처 및 근거

ORD 기록
ord-abd517df60204610939cf68a6c24b096
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722930

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