Sodium Hydroxide → 2-(2,4-Difluorophenoxy)-2-methylpropanoic acid

HRID 389083노트

반응식

HRID 389083 반응식
[OH-].[Na+].[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([O:10]CC)=[O:9]>CO>[F:3][C:4]1[CH:18]=[C:17]([F:19])[CH:16]=[CH:15][C:5]=1[O:6][C:7]([CH3:14])([CH3:13])[C:8]([OH:10])=[O:9]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 1531792HCID 1531792, 화합물

생성물 1

HCID 15318012-(2,4-Difluorophenoxy)-2-methylpropanoic acid수율 98.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

An aqueous sodium hydroxide solution (22.4 ml) was added to a solution of ethyl 2-(2,4-difluorophenoxy)-2-methylpropanoate (2.74 g) in methanol (27.4 ml) under ice cooling, followed by stirring at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure, 1M hydrochloric acid was added thereto followed by extraction with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure to obtain 2-(2,4-difluorophenoxy)-2-methylpropanoic acid (2.38 g) as a colorless oily product.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure, 1M hydrochloric acid
  2. additionwas added
  3. extractionthereto followed by extraction with ethyl acetate
  4. washThe organic layer was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d64fa650d73541fd8fcda35d3e81a274
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377923B2

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