Water → Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate

HRID 389103

반응식

HRID 389103 반응식
[CH:1]1([C:4](=[O:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:3][CH2:2]1.Cl([O-])(=O)(=O)=O.[Mg+2].Cl([O-])(=O)(=O)=O.[Br:22]N1C(=O)CCC1=O.O>C(OCC)(=O)C>[Br:22][CH:5]([C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:10])[C:6]([O:8][CH3:9])=[O:7]

참가 물질

6

반응물 4

HCID 962WaterHCID 24840Magnesium perchlorateHCID 67184N-bromobutanimideHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl Ester

생성물 1

HCID 58243876Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate수율 106.8%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Methyl 3-cyclopropyl-3-oxopropanoate (2.0 g) and magnesium perchlorate (940 mg) were dissolved in ethyl acetate (20 ml), followed by stirring at room temperature for 5 minutes, and N-bromosuccinimide (2.76 g) was added thereto, followed by stirring at room temperature for 4 hours. Water was added thereto, followed by extraction with ethyl acetate, the organic layer was washed with water and saturated brine and was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to obtain, as a colorless oily product, methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.32 g).

후처리

  1. stirringby stirring at room temperature for 4 hours
  2. extractionfollowed by extraction with ethyl acetate
  3. washthe organic layer was washed with water and saturated brine
  4. dry with materialwas dried over anhydrous magnesium sulfate
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-867fd3f19a2344928aaca2959a94929d
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377923B2

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