Thiourea → Methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate hydrobromide
반응식
[Br:1][CH:2]([C:7]([CH:9]1[CH2:11][CH2:10]1)=O)[C:3]([O:5][CH3:6])=[O:4].[NH2:12][C:13]([NH2:15])=[S:14]>C(O)C>[BrH:1].[NH2:15][C:13]1[S:14][C:2]([C:3]([O:5][CH3:6])=[O:4])=[C:7]([CH:9]2[CH2:11][CH2:10]2)[N:12]=1참가 물질
4
반응 조건
- 온도
- 80 °C
실험 절차
Methyl 2-bromo-3-cyclopropyl-3-oxopropanoate (3.3 g) and thiourea (900 mg) were dissolved in ethanol (20 ml) followed by stirring at 80° C. overnight. After cooling to room temperature, the solvent was evaporated under reduced pressure, and the residue was washed with isopropanol to obtain, as a grayish white solid, methyl 2-amino-4-cyclopropyl-1,3-thiazole-5-carboxylate monohydrobromide (2.82 g).
후처리
- temperatureAfter cooling to room temperature
- customthe solvent was evaporated under reduced pressure
- washthe residue was washed with isopropanol
출처 및 근거
- ORD 기록
- ord-a49b409e4d3f46b592b90b530e6029cf
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08377923B2
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