Hydrochloric Acid → Ethyl 3-ethoxy-3-iminopropionate hydrochloride

HRID 389203

반응식

HRID 389203 반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].[CH3:9][CH2:10][OH:11].[ClH:12]>CCOCC>[ClH:12].[CH2:10]([O:11][C:1](=[NH:2])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:9]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 7764Ethyl cyanoacetate

생성물 1

HCID 75345Ethyl 3-ethoxy-3-iminopropionate hydrochloride

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
22 °C

실험 절차

A stirred solution of ethyl cyanoacetate (30 mL, 281 mmol) and EtOH (18.1 mL, 278 mmol) in anhydrous Et2O (28.1 mL), at 0° C., was bubbled with HCl gas until saturated. The reaction was stirred at 22° C. for 20 hours and then concentrated to give the title product. 1H NMR (400 MHz, CDCl3) δ 4.73 (q, J=7.1 Hz, 2H); 4.24 (q, J=7.2 Hz, 2H); 3.89 (s, 2H); 1.51 (t, J=7.0 Hz, 3H); 1.30 (t, J=7.2 Hz, 3H) ppm.

후처리

  1. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b08448825301452abdc32df248ebf72f
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08377874B2

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