3-Methyl-2-butanone → 5-Methoxy-2,3,3-trimethyl-3H-indole

HRID 389239

반응식

HRID 389239 반응식
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10]N)=[CH:6][CH:5]=1.[CH3:12][CH:13]([CH3:17])[C:14](=O)[CH3:15]>C(O)(=O)C>[CH3:2][O:3][C:4]1[CH:9]=[C:8]2[C:7](=[CH:6][CH:5]=1)[N:10]=[C:14]([CH3:15])[C:13]2([CH3:17])[CH3:12]

참가 물질

4

반응물 2

HCID 112513-Methyl-2-butanoneHCID 27239044-Methoxyphenylhydrazine hydrochloride

생성물 1

HCID 110953925-Methoxy-2,3,3-trimethyl-3H-indole

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
10 °C

실험 절차

To 4-methoxyphenyl hydrazine hydrochloride (4.84 g) was added 3-methyl-2-butanone (6.4 ml) and acetic acid (45 ml). The mixture was heated to 10° C. for 2.5 hours after which time the solvent was removed by rotary evaporation. Flash column chromatography gave the product (4.66 g).

후처리

  1. customwas removed by rotary evaporation

출처 및 근거

ORD 기록
ord-0f58494c1ef14cdc90d2e0dcd78b2684
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378120B2

연결된 노트

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