Methyl iodide → Quinolinium, 1,2-dimethyl-6-nitro-, iodide

HRID 389244

반응식

HRID 389244 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([N+:12]([O-:14])=[O:13])[CH:8]=2)[N:3]=1.[I:15][CH3:16]>C(#N)C>[I-:15].[CH3:16][N+:3]1[C:4]2[C:9](=[CH:8][C:7]([N+:12]([O-:14])=[O:13])=[CH:6][CH:5]=2)[CH:10]=[CH:11][C:2]=1[CH3:1]

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 691722-Methyl-6-nitroquinoline

생성물 1

HCID 12252537Quinolinium, 1,2-dimethyl-6-nitro-, iodide수율 16.8%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-Methyl-6-nitroquinoline (0.5 g, 2.66 mmol) and iodomethane (1 ml, 16 mmol) were heated together in acetonitrile (10 ml) at reflux for 48 hrs. The mixture was cooled to room temperature and a grey material crystallised out of solution and was filtered off. This was shown to be starting material. The filtrate was diluted with ethyl acetate (200 ml) to give a yellow/green precipitate. The product was filtered off, washed with ethyl acetate and then dried under vacuum. The product was obtained as a yellow/green solid (147 mg, 16.8%).

후처리

  1. temperatureat reflux for 48 hrs
  2. customa grey material crystallised out of solution
  3. filtrationwas filtered off
  4. additionThe filtrate was diluted with ethyl acetate (200 ml)
  5. customto give a yellow/green precipitate
  6. filtrationThe product was filtered off
  7. washwashed with ethyl acetate
  8. customdried under vacuum

출처 및 근거

ORD 기록
ord-2e1642e27f364759a8acb8c27486709e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378120B2

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