Water → 4-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one

HRID 389312노트

반응식

HRID 389312 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[O:10][C:9](=[O:12])[CH2:8][CH2:7]2.[Cl-].[Cl-].[Cl-].[Al+3].O>CO>[OH:10][C:11]1[C:2]([CH3:1])=[CH:3][CH:4]=[C:5]2[C:6]=1[CH2:7][CH2:8][C:9]2=[O:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 6451240Aluminum(III) ChlorideHCID 235130958-Methyl-3,4-dihydrocoumarin

생성물 1

HCID 668122914-Hydroxy-5-methyl-2,3-dihydro-1H-inden-1-one수율 67.7%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
177.5 °C

실험 절차

The mixture of 8-Methyl dihydrocoumarin (20 gm, 0.123 mole) and Aluminum trichloride (49.3 gm, 0.370 mole) was stirred for 2 hours at 175-180° C. To the reaction mixture, water (250 ml) was added slowly and stirred for an hour. Further it was filtered and obtained solid was stirred in Methanol (60 ml). Finally the suspension was filtered and obtained solid was dried under vacuum to give 13.5 gm of desired product as a solid.

후처리

  1. stirringstirred for an hour
  2. filtrationFurther it was filtered
  3. customobtained solid
  4. filtrationFinally the suspension was filtered
  5. customobtained solid
  6. customwas dried under vacuum

출처 및 근거

ORD 기록
ord-315445d0dd5c4e439bf36c7c5047aa8d
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378118B2

반응 노트

불러오는 중…