N-Iodosuccinimide → 7-Bromo-5-iodo-1,2,3-benzothiadiazol-4-amine
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:11])=[C:6]2[C:10]=1[S:9][N:8]=[N:7]2.C1C(=O)N([I:19])C(=O)C1>C1COCC1>[Br:1][C:2]1[CH:3]=[C:4]([I:19])[C:5]([NH2:11])=[C:6]2[C:10]=1[S:9][N:8]=[N:7]2참가 물질
4
실험 절차
A mixture of 7-bromo-1,2,3-benzothiadiazol-4-amine (80.0 mg, 0.348 mmol) and NIS (117.3 mg, 0.522 mmol) in THF (6 ml) was stirred at RT overnight. The solution was adsorbed onto silica gel and purified by ISCO chromatography (10 to 30% EtOAc:heptane) to afford 95 mg (77%) of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ 6.89 (s, 2 H), 8.05 (s, 1 H).
후처리
- custompurified by ISCO chromatography (10 to 30% EtOAc:heptane)
출처 및 근거
- ORD 기록
- ord-a725ace4fc094a08b3a9de8c26ac2396
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08378104B2
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