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Diisopropylethylamine → 5-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

HRID 389644
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HRID 389644 반응식
[NH2:1][C@H:2]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]1[CH3:21])=[O:14])[CH2:3][NH:4][C:5]([C:7]1[S:8][C:9]([Cl:12])=[CH:10][CH:11]=1)=[O:6].CCN(C(C)C)C(C)C.[CH2:31]([C:33]1[C:38]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][C:40]2=[O:45])=[CH:37][CH:36]=[CH:35][C:34]=1[S:46](Cl)(=[O:48])=[O:47])[CH3:32]>C(Cl)Cl>[CH2:31]([C:33]1[C:38]([N:39]2[CH2:44][CH2:43][O:42][CH2:41][C:40]2=[O:45])=[CH:37][CH:36]=[CH:35][C:34]=1[S:46]([NH:1][C@H:2]([C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][C@@H:16]1[CH3:21])=[O:14])[CH2:3][NH:4][C:5]([C:7]1[S:8][C:9]([Cl:12])=[CH:10][CH:11]=1)=[O:6])(=[O:47])=[O:48])[CH3:32]
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참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 671552485-Chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide2회HCID 727928892-Ethyl-3-(3-oxomorpholino)benzene-1-sulfonyl chloride2회

생성물 1

HCID 442008555-Chloro-thiophene-2-carboxylic acid [(S)-2-[2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonylamino]-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide

시약·촉매·용매

1
HCID 6344Dichloromethane용매2회

실험 절차

5-Chloro-thiophene-2-carboxylic acid [(S)-2-amino-3-((S)-3-methyl-morpholin-4-yl)-3-oxo-propyl]-amide, Intermediate 3 (95 mg, 0.287 mmol) was dissolved in 2 ml DCM and DIPEA (151 μl, 0.861 mmol). 2-ethyl-3-(3-oxo-morpholin-4-yl)-benzenesulfonyl chloride, Intermediate 7 (91 mg, 0.3 mmol) in 2 ml DCM was slowly added and the reaction was stirred for 75 min. After that the solution was evaporated to dryness and purified by prep. HPLC. After lyophilization the title compound was obtained as colorless, amorphous solid. Yield: 108 mg, 63%

후처리

  1. customAfter that the solution was evaporated to dryness
  2. custompurified by prep

출처 및 근거

ORD 기록
ord-60fc9bf5f8064fc0a10549b3ec2b68fc
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08378092B2

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