2,6-Difluorobenzoic acid → Sodium 2,6-difluorobenzoate

HRID 389696노트

반응식

HRID 389696 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+:13]>CCO.O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([O-:6])=[O:5].[Na+:13]

참가 물질

5

반응물 2

HCID 97962,6-Difluorobenzoic acidHCID 14798Sodium Hydroxide

생성물 1

HCID 23698872Sodium 2,6-difluorobenzoate수율 100%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 2,6-difluorobenzoic acid (1.00 g, 6.3 mmol) in EtOH and water (5:1, 60 mL) was added 1N aqueous sodium hydroxide solution (6.33 mL, 6.3 mmol). The reaction mixture was stirred for 10 minutes at room temperature and then solvents were removed in vacuo to yield sodium 2,6-difluorobenzoate (1.22 g, 6.3 mmol, quantitative) as an off white solid. 1H NMR (DMSO) δ 6.89 (2H, m), 7.15 (1H, m).

후처리

  1. customsolvents were removed in vacuo

출처 및 근거

ORD 기록
ord-3bb7b79af1a34891b64d1777f159f6db
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08378095B2

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