Sodium Hydroxide → HCID 66879256, 화합물

HRID 39006노트

반응식

HRID 39006 반응식
C([O:4][C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([F:12])[C:6]=1[O:13][CH2:14][C@H:15]1[CH2:17][O:16]1)(=O)C.[OH-].[Na+]>O1CCOCC1>[Br:11][C:9]1[CH:8]=[C:7]([F:12])[C:6]2[O:13][CH2:14][C@H:15]([CH2:17][OH:16])[O:4][C:5]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866529465-Bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate

생성물 1

HCID 66879256HCID 66879256, 화합물

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1-(5-bromo-3-fluoro-2-[(2R)-oxiran-2-ylmethoxy]phenyl acetate (crude, max 67 mmol) was stirred in dioxane at 0° C. NaOH (15%) was added until the mixture reached pH 14. The mixture was stirred for 30 min at RT and then concentrated. Water was added and the mixture extracted with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated to dryness to give the crude title compound. Yield: 10.3 g. MS m/z (rel. intensity, 70 eV) 262 (M+, bp), 264 (M+, bp), 206 (70), 81 (58), 69 (55), 57 (53).

후처리

  1. concentrationconcentrated
  2. additionWater was added
  3. extractionthe mixture extracted with EtOAc
  4. washThe combined organic phases were washed with brine
  5. dry with materialdried (Na2SO4)
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-32a2f494200a4a5bbc14c29820a1e1b8
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

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