N-bromobutanimide → HCID 58296328, 화합물

HRID 390062노트

반응식

HRID 390062 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:10]3[C:20](=[O:21])[NH:19][CH:18]=[CH:17][C:11]=3[N:12]=[C:13]([S:15][CH3:16])[N:14]=2)[CH:5]=[CH:6][CH:7]=1.C1C(=O)N([Br:29])C(=O)C1>CN(C)C=O>[Br:29][C:17]1[C:11]2[N:12]=[C:13]([S:15][CH3:16])[N:14]=[C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=3)[C:10]=2[C:20](=[O:21])[NH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 58296312HCID 58296312, 화합물

생성물 1

HCID 58296328HCID 58296328, 화합물수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-[(3-methylphenyl)amino]-2-(methylthio)pyrido[4,3-d]pyrimidin-5(6H)-one (500 mg, 1.676 mmol) was dissolved into N,N-Dimethylformamide (DMF) (8 mL) and NBS (298 mg, 1.676 mmol) was added. The reaction mixture was stirred at rt for 2 h. It was quenched with water (12 mL) and EtOAc (5 mL) was added. The mixture was filtered to collect the precipitate, which was further dried under high vacuum to give 470 mg of crude product (83% pure based on LC-MS).

후처리

  1. additionwas added
  2. customIt was quenched with water (12 mL) and EtOAc (5 mL)
  3. additionwas added
  4. filtrationThe mixture was filtered
  5. customto collect the precipitate, which
  6. customwas further dried under high vacuum

출처 및 근거

ORD 기록
ord-73345933f8024366b423f3153a7150da
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383635B2

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