7-bromo-2',3'-dihydro-1'H-spiro[isoindoline-1,4'-pyridin]-3-one → 7-Bromospiro[isoindoline-1,4'-piperidin]-3-one

HRID 390138노트

반응식

HRID 390138 반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH:14]=[CH:13][NH:12][CH2:11][CH2:10]1)[NH:8][C:7]2=[O:16]>CC(O)=O.O=[Pt]=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:15]=1[C:9]1([CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)[NH:8][C:7]2=[O:16]

참가 물질

4

반응물 1

HCID 582957447-bromo-2',3'-dihydro-1'H-spiro[isoindoline-1,4'-pyridin]-3-one

생성물 1

HCID 582957267-Bromospiro[isoindoline-1,4'-piperidin]-3-one수율 100%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 176Acetic Acid용매

실험 절차

A solution of 7-bromo-2′,3′-dihydro-1′H-spiro[isoindoline-1,4′-pyridin]-3-one (2 g, 0.0072 mol) in CH3COOH was hydrogenated in the presence of PtO2 for 1.5 h. The catalyst was removed by filtration and the filtrate was concentrated to give the crude product which was washed with saturated aq Na2CO3. The solvent was removed to give the 7-bromospiro[isoindoline-1,4′-piperidin]-3-one (2 g, 100%).

후처리

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated
  3. customto give the crude product which
  4. washwas washed with saturated aq Na2CO3
  5. customThe solvent was removed

출처 및 근거

ORD 기록
ord-fa458ef465bd4795b4d1554c03548242
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383629B2

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