D-Psicose → Ethyl 7-hydroxychromane-2-carboxylate

HRID 39036

반응식

HRID 39036 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=O)[CH:7]=[C:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[O:9]2)=[CH:4][CH:3]=1.OCC1(OC[C@@H](O)[C@@H](O)[C@H]1O)O>CO.CC(O)=O>[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[O:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 441036D-PsicoseHCID 5376802ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate

생성물 1

HCID 11085381Ethyl 7-hydroxychromane-2-carboxylate

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 887Methanol용매

실험 절차

A mixture of ethyl 7-hydroxy-4-oxo-4H-chromene-2-carboxylate (10 g, 41 mmol) in MeOH (20 ml) and AcOH (20 ml) was hydrogenated at 50 Psi for 4 days. Filtration and evaporation gave the title compound. Yield: 9.2 g. MS m/z (rel. intensity, 70 eV) 222 (M+, 44), 149 (bp), 148 (22), 147 (46), 121 (25).

후처리

  1. filtrationFiltration and evaporation

출처 및 근거

ORD 기록
ord-16cef5a5643c4731bb66f34f4859aff1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524766B2

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