Triethylamine → Ethyl [5-(5-bromo-1,3,4-thiadiazol-2-yl)-2H-tetrazol-2-yl]acetate
반응식
[Br:1][C:2]1[S:6][C:5]([C:7]#[N:8])=[N:4][N:3]=1.BrC1SC(C(N)=O)=[N:12][N:11]=1.CC[N:20](CC)CC.[C:25]([O:31][C:32]([C:34](F)(F)F)=O)([C:27](F)(F)F)=[O:26]>C1COCC1>[Br:1][C:2]1[S:6][C:5]([C:7]2[N:20]=[N:11][N:12]([CH2:27][C:25]([O:31][CH2:32][CH3:34])=[O:26])[N:8]=2)=[N:4][N:3]=1참가 물질
6
실험 절차
5-Bromo-1,3,4-thiadiazole-2-carbonitrile To a solution of 5-bromo-1,3,4-thiadiazole-2-carboxamide and Et3N (2.3 equiv) in THF (0.5 M) at 0° C. was added TFAA (1.1 equiv). The mixture was then warmed to room temperature and stirred for 30 min, then the solvent was evaporated in vacuo. The resulting residue was diluted with water. The resulting precipitate was collected, washed with water, and dried to give the title compound.
후처리
- customthe solvent was evaporated in vacuo
- additionThe resulting residue was diluted with water
- customThe resulting precipitate was collected
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-ceded20fa0854a9f830da425584a44db
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08383643B2
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