Ammonia → 5-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole

HRID 390442

반응식

HRID 390442 반응식
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[N:6][CH:5]=1.[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)#[CH:12].N>>[F:19][C:15]1[CH:14]=[C:13]([C:11]2[O:1][N:2]=[C:3]([C:4]3[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=3)[CH:12]=2)[CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 5202181-Ethynyl-3-fluorobenzeneHCID 53404818N-Hydroxy-3-pyridinecarboximidoyl chloride

생성물 1

HCID 445462235-(3-Fluorophenyl)-3-(pyridin-3-yl)isoxazole

실험 절차

The titled compound was prepared as the hydrochloride salt according to Method CB using the product of Example 1A (78 mg, 0.5 mmol) and 1-ethynyl-3-fluorobenzene (Aldrich, 60 mg, 0.5 mmol). 1H NMR (300 MHz, DMSO-d6) δ 7.35-7.51 (m, 1H), 7.60-7.82 (m, 4H), 7.84 (s, 1H), 8.42 (dt, J=8.1, 1.7 Hz, 1H), 8.80 (dd, J=5.0, 1.4 Hz, 1H), 9.17 (d, J=1.6 Hz, 1H) ppm; MS (DCI/NH3) m/z 241 (M+H)+.

출처 및 근거

ORD 기록
ord-c9dd3195296b4b4a85420eb9e3c68bec
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

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