Ammonia → 3-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile

HRID 390461

반응식

HRID 390461 반응식
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:11]=1)[C:7](Cl)=[N:8][OH:9].[C:12]([C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[C:17]#[N:18])#[CH:13].N>>[F:1][C:2]1[CH:11]=[C:6]([C:7]2[CH:13]=[C:12]([C:14]3[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=3)[C:17]#[N:18])[O:9][N:8]=2)[CH:5]=[N:4][CH:3]=1

참가 물질

4

반응물 3

HCID 222AmmoniaHCID 120889643-EthynylbenzonitrileHCID 866368465-Fluoro-N-hydroxynicotinimidoyl chloride

생성물 1

HCID 445462873-(3-(5-Fluoropyridin-3-yl)isoxazol-5-yl)benzonitrile

실험 절차

The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and the product of Example 19A (64 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) δ 7.55 (s, 1H), 7.75 (t, J=7.9 Hz, 1H), 7.88 (dt, J=7.9, 1.4 Hz, 1H), 8.18 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.23 (ddd, J=7.9, 2.0, 1.2 Hz, 1H), 8.31 (t, J=1.6 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.98 (t, J=1.6 Hz, 1 H) ppm; MS (DCI/NH3) m/z 266 (M+H)+.

출처 및 근거

ORD 기록
ord-44d5ca19e8cc4beea375f60dd735de39
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383658B2

연결된 노트

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