Cyclohexylamine → ethyl (Z)-3-[3'-(3-cyclohexyl-1-methylureido)biphenyl-4-yl]-2-ethoxyacrylate
반응식
[CH2:1]([O:3]/[C:4](=[CH:10]\[C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([N:23]([CH3:36])[C:24]([O:26]C3C=CC([N+]([O-])=O)=CC=3)=O)[CH:18]=2)=[CH:13][CH:12]=1)/[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:2].[CH:37]1([NH2:43])[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1>>[CH:37]1([NH:43][C:24](=[O:26])[N:23]([C:19]2[CH:18]=[C:17]([C:14]3[CH:13]=[CH:12][C:11](/[CH:10]=[C:4](\[O:3][CH2:1][CH3:2])/[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[CH:16][CH:15]=3)[CH:22]=[CH:21][CH:20]=2)[CH3:36])[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1참가 물질
3
실험 절차
In a manner similar to that of Example 43d, starting with 1.75 g (3 mmol) of ethyl (Z)-2-ethoxy-3-{3′-[methyl(4-nitrophenoxycarbonyl)amino]biphenyl-4-yl}acrylate (prepared according to Example 43c) and 0.42 mL (3.7 mmol) of cyclohexylamine, 0.7 g (50%) of ethyl (Z)-3-[3′-(3-cyclohexyl-1-methylureido)biphenyl-4-yl]-2-ethoxyacrylate is obtained.
출처 및 근거
- ORD 기록
- ord-17993720cd4241d08709f1052e2e806d