Methyl iodide → (NZ)-3-methyl-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazol-3-ium-1-carboxamide;iodide

HRID 390696노트

반응식

HRID 390696 반응식
[CH3:1][C:2]1[S:6]/[C:5](=[N:7]\[C:8]([N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)=[O:9])/[N:4]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[CH:3]=1.[I:25][CH3:26]>C(#N)C>[I-:25].[CH3:26][N+:12]1[CH:13]=[CH:14][N:10]([C:8](/[N:7]=[C:5]2\[S:6][C:2]([CH3:1])=[CH:3][N:4]\2[C:15]2[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=2)=[O:9])[CH:11]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 87450752(NZ)-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazole-1-carboxamide

생성물 1

HCID 87447393(NZ)-3-methyl-N-[5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-ylidene]imidazol-3-ium-1-carboxamide;iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-[(2Z)-5-methyl-3-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2(3H)-ylidene]-1H-imidazole-1-carboxamide (2.0 g, 5.68 mmol, Example 18A) in acetonitrile (10 mL) was treated with iodomethane (3 mL). The mixture was stirred at room temperature for five days, the solvent was evaporated, and the title product was used directly for the next step.

후처리

  1. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-c97093caa2754b079764acbc5cafc707
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383657B2

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