Hydrochloric Acid → 1-(Thiophene-2-sulfonyl)piperazine hydrochloride
반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CO.ClCCl.C(OCC)C>[ClH:22].[S:18]1[CH:19]=[CH:20][CH:21]=[C:17]1[S:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)(=[O:16])=[O:15]참가 물질
6
실험 절차
4-(2-Thiophenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (759 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (11.4 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-thiophenesulfonyl)-piperazine hydrochloride salt (529 mg).
후처리
- temperaturecooled in ice bath
- filtrationthe resulted precipitate was filtered
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-9b0aa01a386e49b6b194060d6771ce59
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08383620B2
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