Hydrochloric Acid → 1-(4-Fluorobenzenesulfonyl)piperazine hydrochloride

HRID 390991노트

반응식

HRID 390991 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>CO.ClCCl.C(OCC)C>[ClH:24].[F:23][C:20]1[CH:19]=[CH:18][C:17]([S:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)(=[O:16])=[O:15])=[CH:22][CH:21]=1

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 4634543HCID 4634543, 화합물

생성물 1

HCID 173683141-(4-Fluorobenzenesulfonyl)piperazine hydrochloride

시약·촉매·용매 3

HCID 887Methanol용매HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

4-(4-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (937 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (13.6 ml) was added and the reaction mixture was stirred at room temperature overnight. Volatiles were removed in vacuo to yield 4-(4-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (819 mg).

후처리

  1. customVolatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-bba8de4c52164eee843962ab9e57b083
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

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