Sodium borohydride → (5-Bromopyridin-2-yl)methanol

HRID 391076

반응식

HRID 391076 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]=[O:9])=[N:6][CH:7]=1.[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][OH:9])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 98775625-Bromopyridine-2-carbaldehyde

생성물 1

HCID 5200169(5-Bromopyridin-2-yl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-bromopyridine-2-carbaldehyde (300 mg) in methanol (10 mL) was added sodium borohydride (61 mg) and the reaction stirred at room temperature for 72 h. The reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL) and extracted into dichloromethane (3×30 mL). The organic layers were dried (MgSO4) and reduced in vacuo to give (5-bromo-pyridin-2-yl)-methanol as a white solid.

후처리

  1. customThe reaction was quenched with saturated aqueous sodium carbonate solution (20 mL) and water (20 mL)
  2. extractionextracted into dichloromethane (3×30 mL)
  3. dry with materialThe organic layers were dried (MgSO4)

출처 및 근거

ORD 기록
ord-d50072c653d44d7ea55d70ddb7fd33ee
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383620B2

연결된 노트

불러오는 중…