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1,2-Dichloroethane → HCID 58149347, 화합물

HRID 391216
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HRID 391216 반응식
[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([OH:14])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl.[OH:32][C:33]12[CH2:42][CH:37]3[CH2:38][CH:39]([CH2:41][CH:35]([CH:36]3[NH:43][CH3:44])[CH2:34]1)[CH2:40]2.CCN(C(C)C)C(C)C>CN(C=O)C>[CH:1]1([CH2:7][O:8][C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([N:43]([CH:36]2[CH:37]3[CH2:38][CH:39]4[CH2:40][C:33]([OH:32])([CH2:34][CH:35]2[CH2:41]4)[CH2:42]3)[CH3:44])=[O:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1
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참가 물질

7

반응물 5

HCID 111,2-DichloroethaneHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 37214804-(Methylamino)adamantan-1-olHCID 18544082HCID 18544082, 화합물

생성물 1

HCID 58149347HCID 58149347, 화합물수율 39.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
20 °C

실험 절차

3-Cyclohexylmethoxy-benzoic acid (300 mg, 1.3 mmol), HOBT (294 mg, 1.9 mmol), EDC (245 mg, 1.3 mmol), and 1-hydroxy-4-methylaminoadamantane (232 mg, 1.28 mmol) were suspended in DMF (2.5 ml) before DIPEA (0.44 ml, 2.6 mmol) was added. The reaction mixture was stirred at 20° C. overnight. The reaction mixture was purified directly by Preparative HPLC to give 199 mg of the title compound as a mixture of two isomers.

후처리

  1. additionwas added
  2. customThe reaction mixture was purified directly by Preparative HPLC

출처 및 근거

ORD 기록
ord-fe3a7d92233344399acb1c2e3de2c89f
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08383820B2

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