4-Chloro-6-(chloromethyl)pyrimidin-2-amine → 2-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

HRID 3915노트

반응식

HRID 3915 반응식
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1>C(OCC)C.Cl>[ClH:8].[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([CH2:9][Cl:10])[N:3]=1

참가 물질

4

반응물 1

HCID 201534884-Chloro-6-(chloromethyl)pyrimidin-2-amine

생성물 1

HCID 201535002-Amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 3283Diethyl Ether용매

실험 절차

3.56 Parts of 2-amino-4-chloro-6-chloromethylpyrimidine was dissolved in 53 parts of dry diethyl ether and dry hydrogen chloride was bubbled through the solution, with stirring, until no further solid precipitated the solid was filtered, washed with ether and dried in vacuo. Recrystallisation from acetone gave 2-amino-4-chloro-6-chloromethyl-pyrimidine hydrochloride m.p. 145°-150° C. (decomposition).

후처리

  1. customwas bubbled through the solution
  2. customprecipitated the solid
  3. filtrationwas filtered
  4. washwashed with ether
  5. customdried in vacuo
  6. customRecrystallisation from acetone

출처 및 근거

ORD 기록
ord-58de8242ae774164a8154c623f6db4b7
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723006

반응 노트

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