Dichloromethane → 1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarbonyl chloride
반응식
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([C:13]([OH:15])=O)[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1.C(Cl)[Cl:17].S(Cl)(Cl)=O>CN(C)C=O>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3([C:13]([Cl:17])=[O:15])[CH2:12][CH2:11]3)=[CH:9][C:4]=2[O:3][CH2:2]1참가 물질
5
실험 절차
To an oven-dried round bottom flask containing 1-(benzo[d][1,3]dioxol-5-yl)-cyclopropanecarboxylic acid (A-8) (618 mg, 3.0 mmol) and CH2Cl2 (3 mL) was added thionyl chloride (1.07 g, 9.0 mmol) and N,N-dimethylformamide (0.1 mL). The reaction mixture was stirred at ambient temperature under an Ar atmosphere until the gas evolution ceased (2-3 h). The excess thionyl chloride was removed under vacuum and the resulting residue dissolved in CH2Cl2 (3 mL). The mixture was used without further manipulation.
후처리
- custom(2-3 h)
- customThe excess thionyl chloride was removed under vacuum
- dissolutionthe resulting residue dissolved in CH2Cl2 (3 mL)
출처 및 근거
- ORD 기록
- ord-149e3eca1b604a8aa9b6b65372c7188b
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524767B2
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