Hydrochloric Acid → HCID 66719276, 화합물

HRID 391862노트

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HRID 391862 반응식
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][C@@H:7]([C:12]([OH:14])=[O:13])[NH:8][CH2:9]2)=[CH:4][CH:3]=1.[ClH:15].[CH3:16]O>>[ClH:15].[CH3:16][O:13][C:12]([C@@H:7]1[CH2:6][C:5]2[C:10](=[CH:11][C:2]([OH:1])=[CH:3][CH:4]=2)[CH2:9][NH:8]1)=[O:14]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 2733173(3S)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

생성물 1

HCID 66719276HCID 66719276, 화합물

반응 조건

온도
70 °C

실험 절차

To a solution of (S)-7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (19.3 g) in 100 mL MeOH was added hydrochloric acid (100 mL, 4M solution in dioxane) at room temperature and the reaction mixture was heated to reflux and stirred at 70° C. for 16 hours. After completion of the reaction the reaction mixture was concentrated in vacuo to give (S)-7-hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid methyl ester hydrochloride salt with quantitative yield. The product was used in the next step without further purification.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureto reflux
  3. customAfter completion of the reaction the reaction mixture
  4. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-4b00211f4eba4349a555352ab81ff9da
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08383644B2

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