Sodium ethoxide → 4-Azaindole

HRID 392129

반응식

HRID 392129 반응식
FC(F)(F)C([NH:5][C:6]1[C:7]([C:12]#[C:13][Si](C)(C)C)=[N:8][CH:9]=[CH:10][CH:11]=1)=O.[O-]CC.[Na+]>C(O)C>[NH:5]1[C:6]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:12]=[CH:13]1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 121468532,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide

생성물 1

HCID 92264-Azaindole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.

후처리

  1. temperatureis heated
  2. temperatureat reflux temperature for 10 h
  3. temperaturecooled
  4. concentrationconcentrated in vacuo
  5. customThe resultant residue is purified by preparative reverse phase HPLC

출처 및 근거

ORD 기록
ord-2930650ca1d249b885405ad26de4d25a
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06800640B2

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