Sodium ethoxide → 4-Azaindole
반응식
FC(F)(F)C([NH:5][C:6]1[C:7]([C:12]#[C:13][Si](C)(C)C)=[N:8][CH:9]=[CH:10][CH:11]=1)=O.[O-]CC.[Na+]>C(O)C>[NH:5]1[C:6]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[CH:12]=[CH:13]1참가 물질
4
실험 절차
A mixture of 2,2,2-trifluoro-N-(2-trimethylsilanylethynylpyridin-3-yl)acetamide (1.0 eq) and sodium ethoxide (5 eq.) in ethanol is heated at reflux temperature for 10 h, cooled and concentrated in vacuo. The resultant residue is purified by preparative reverse phase HPLC to give the title 4-azaindole.
후처리
- temperatureis heated
- temperatureat reflux temperature for 10 h
- temperaturecooled
- concentrationconcentrated in vacuo
- customThe resultant residue is purified by preparative reverse phase HPLC
출처 및 근거
- ORD 기록
- ord-2930650ca1d249b885405ad26de4d25a
- 출처 데이터셋
- uspto-grants-2004_10
- 특허 번호
- US06800640B2
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