Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

HRID 39224

반응식

HRID 39224 반응식
[C:1]([C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[S:10](Cl)(=[O:12])=[O:11])#[N:2].[S:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>O1CCCC1>[F:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([S:10]([N:16]2[CH2:17][CH2:18][S:14][CH2:15]2)(=[O:12])=[O:11])[C:3]=1[C:1]#[N:2]

참가 물질

4

반응물 2

HCID 10444ThiazolidineHCID 205052122-Cyano-3-fluorobenzene-1-sulfonyl chloride

생성물 1

HCID 442186552-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.

후처리

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customPurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
  3. washby acidic washing with a 1M HCl solution

출처 및 근거

ORD 기록
ord-62d17e228e394a5fafc800d9e62ffeab
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524896B2

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