Thiazolidine → 2-Fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile
반응식
[C:1]([C:3]1[C:8]([F:9])=[CH:7][CH:6]=[CH:5][C:4]=1[S:10](Cl)(=[O:12])=[O:11])#[N:2].[S:14]1[CH2:18][CH2:17][NH:16][CH2:15]1>O1CCCC1>[F:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([S:10]([N:16]2[CH2:17][CH2:18][S:14][CH2:15]2)(=[O:12])=[O:11])[C:3]=1[C:1]#[N:2]참가 물질
4
실험 절차
440 mg of 2-cyano-3-fluoro-benzenesulfonyl chloride in 10 ml of tetrahydrofuran are treated with 0.36 ml of thiazolidine and the mixture is stirred for 16 hours at room temperature. The reaction mixture is concentrated in vacuo. Purification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1) followed by acidic washing with a 1M HCl solution affords 318 mg of 2-fluoro-6-(thiazolidine-3-sulfonyl)-benzonitrile.
후처리
- concentrationThe reaction mixture is concentrated in vacuo
- customPurification by Flash chromatography (eluent: cyclohexane/ethyl acetate 1:1)
- washby acidic washing with a 1M HCl solution
출처 및 근거
- ORD 기록
- ord-62d17e228e394a5fafc800d9e62ffeab
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524896B2
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