Ammonia → HCID 135674105, 화합물

HRID 392311노트

반응식

HRID 392311 반응식
[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8]#[N:9].Cl.[NH3:11]>CO>[O:1]=[C:2]1[NH:7][CH:6]=[CH:5][N:4]=[C:3]1[C:8](=[NH:11])[NH2:9]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 129137633-Oxo-3,4-dihydropyrazine-2-carbonitrile

생성물 1

HCID 135674105HCID 135674105, 화합물

시약·촉매·용매 1

HCID 887Methanol용매2회

실험 절차

In 33 ml of methanol was dissolved 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarbonitrile synthesized according to the description of J. Heterocycl. Chem., Vol. 19, Pages 1,397-1,402 (1982). While cooling the solution with ice, gaseous hydrogen chloride was introduced until saturation, after which the solution was stirred at the same temperature as above for 8 hours. The solvent was removed under reduced pressure, the residue thus obtained and dissolved in 55 ml of a 7 mol/L solution of ammonia in methanol at an ice-cooled temperature, and the solution thus obtained was stirred at the same temperature as above for 5 minutes. The solid product formed was collected by filtration to obtain 1.1 g of 3-oxo-3,4-dihydro-2-pyrazinecarboximidamide as a light yellow-colored solid product.

후처리

  1. customsynthesized
  2. additionwas introduced until saturation
  3. customThe solvent was removed under reduced pressure
  4. customthe residue thus obtained
  5. temperaturecooled temperature
  6. customthe solution thus obtained
  7. stirringwas stirred at the same temperature as above for 5 minutes
  8. customThe solid product formed
  9. filtrationwas collected by filtration

출처 및 근거

ORD 기록
ord-b7f83cb9b6c54596aa57078c71f6063f
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06800629B2

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