2-Fluorophenol → HCID 69880868, 화합물

HRID 392416노트

반응식

HRID 392416 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[OH:23]>>[F:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[O:23][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH2:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 97072-FluorophenolHCID 7427744-bromo-N-(pyridin-3-ylmethyl)aniline

생성물 1

HCID 69880868HCID 69880868, 화합물

실험 절차

Using the method of Example 342 using N-(4-bromophenyl)pyridin-3-ylmethylamine and 2-fluorophenol (Aldrich)and purifying via preparative HPLC eluting with 90:10 to 80:20 DCM/ethyl acetate gave N-(4-(2-fluorophenoxy)phenyl)pyrid-3-ylmethylamine. Anal Calcd for C18H15FN2O: C, 73.45; H, 5.14; N, 9.52. Found: C, 73.36; H, 5.22; N, 9.35. MS found 295.1 [M+H]+

후처리

  1. custompurifying via preparative HPLC
  2. washeluting with 90:10 to 80:20 DCM/ethyl acetate

출처 및 근거

ORD 기록
ord-25cfcd47a3e3473093357d9d679fd19e
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06800651B2

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