Trifluoroacetic acid → 2-Oxoethyl butyrate

HRID 39253

반응식

HRID 39253 반응식
[C:1]([O:6][CH2:7][CH:8](OC)[O:9]C)(=[O:5])[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([O:6][CH2:7][CH:8]=[O:9])(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 113673002,2-Dimethoxyethyl butyrate

생성물 1

HCID 98988312-Oxoethyl butyrate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Compound 43a (176 mg, 1.0 mmol) was dissolved in 8 mL of CH2Cl2 and 4 mL of TFA (containing 5% H2O) was added. The mixture was stirred for 30 min at room temperature. The solution was then concentrated in vacuo to give the product 44a that was used immediately for the next step. 1H NMR (400 MHz, CDCl3) δ 0.92 (m, 3H), 1.64 (m, 2H), 2.24 (t, J=7.04 Hz, 2H), 4.72 (s, 2H), 9.60 (s, 1H).

후처리

  1. concentrationThe solution was then concentrated in vacuo

출처 및 근거

ORD 기록
ord-8994c8ce8da447d3a3b5ecdf901c759e
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524691B2

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