Iodine → HCID 178516519, 화합물
반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1.C([O-])([O-])=O.[K+].[K+].[I:15]I.OS([O-])(=O)=O.[K+]>O>[OH:1][C:2]1[C:7]([I:15])=[C:6]([OH:8])[CH:5]=[CH:4][N:3]=1참가 물질
6
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 2,4-dihydroxypyridine (1.0 eq), K2CO3 (1.0 eq), and water was stirred at 100° C. so that it became homogeneous. With continued stirring and heating, I2 (1.0 eq) was added in portions, causing the evolution of gas. When the solid I2 was consumed, the mixture was cooled and acidified with aqueous KHSO4 (1.0 eq), generating a precipitate. The precipitate was collected by filtration, rinsed with water, and stored under high vacuum, to give 2,4-dihydroxy-3-iodopyridine.
후처리
- stirringWith continued stirring
- temperatureheating
- customWhen the solid I2 was consumed
- temperaturethe mixture was cooled
- filtrationThe precipitate was collected by filtration
- washrinsed with water
출처 및 근거
- ORD 기록
- ord-20f24aedfaa64334b81c5857dc084546
- 출처 데이터셋
- uspto-grants-2004_10
- 특허 번호
- US06803370B2
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