Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide

HRID 392830

반응식

HRID 392830 반응식
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1.C([O-])(O)=O.[Na+].[C:20](Cl)(=[O:22])[CH3:21]>C(Cl)Cl>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:20](=[O:22])[CH3:21])[CH:2]=1

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 516892Sodium BicarbonateHCID 27603683-(Aminomethyl)biphenyl

생성물 1

HCID 22660935N-biphenyl-3-ylmethyl-acetamide수율 128.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.

후처리

  1. customThe organic layer was separated
  2. washwashed with satd NaCl
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. customsolvent removed under vacuum

출처 및 근거

ORD 기록
ord-dedfeb76dab54b4b9c853a25bd0c6433
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06803378B2

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