Acetyl chloride → N-biphenyl-3-ylmethyl-acetamide
반응식
[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH2:8])[CH:2]=1.C([O-])(O)=O.[Na+].[C:20](Cl)(=[O:22])[CH3:21]>C(Cl)Cl>[C:1]1([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][NH:8][C:20](=[O:22])[CH3:21])[CH:2]=1참가 물질
5
실험 절차
C-Biphenyl-3-yl-methylamine (700 mg, 3.8 mmol) was dissolved in 38 mL of CH2Cl2. To this was added 38 mL of satd NaHCO3 (aq) followed by acetyl chloride (1.41 mL 19,8 mmol). The resulting mixture was stirred 45 min. The organic layer was separated, washed with satd NaCl, dried over Na2SO4, filtered and solvent removed under vacuum to yield 1.1 grams of N-biphenyl-3-ylmethyl-acetamide.
후처리
- customThe organic layer was separated
- washwashed with satd NaCl
- dry with materialdried over Na2SO4
- filtrationfiltered
- customsolvent removed under vacuum
출처 및 근거
- ORD 기록
- ord-dedfeb76dab54b4b9c853a25bd0c6433
- 출처 데이터셋
- uspto-grants-2004_10
- 특허 번호
- US06803378B2
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