홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → 4-[[2-carboxy-5-(3,3-dimethyl-but-1-ynyl)-thiophen-3-yl]-(4-methyl-cyclohexanecarbonyl)-amino]-piperidine-1-carboxylic acid hexahydro-furo[2,3-b]furan-3-(R)-yl ester

HRID 39294
노트
인쇄 미리보기

반응식

HRID 39294 반응식
Cl.C[O:3][C:4]([C:6]1[S:7][C:8]([C:27]#[C:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[CH:9][C:10]=1[N:11]([C:18]([CH:20]1[CH2:25][CH2:24][CH:23]([CH3:26])[CH2:22][CH2:21]1)=[O:19])[CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)=[O:5].[O:33]1[CH:37]2[O:38][CH2:39][CH2:40][CH:36]2[C@@H:35]([O:41][C:42](=[O:52])C2C=CC([N+]([O-])=O)=CC=2)[CH2:34]1.O1CCC(O)CC1>>[O:33]1[CH:37]2[O:38][CH2:39][CH2:40][CH:36]2[C@@H:35]([O:41][C:42]([N:15]2[CH2:16][CH2:17][CH:12]([N:11]([C:10]3[CH:9]=[C:8]([C:27]#[C:28][C:29]([CH3:32])([CH3:30])[CH3:31])[S:7][C:6]=3[C:4]([OH:3])=[O:5])[C:18]([CH:20]3[CH2:25][CH2:24][CH:23]([CH3:26])[CH2:22][CH2:21]3)=[O:19])[CH2:13][CH2:14]2)=[O:52])[CH2:34]1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 74956Tetrahydro-4H-pyran-4-olHCID 583558385-(3,3-Dimethyl-but-1-ynyl)-3-[(4-methyl-cyclohexanecarbonyl)-piperidin-4-yl-amino]-thiophene-2-carboxylic acid methyl esterHCID 673206824-nitro-benzoic acid hexahydro-furo[2,3-b]furan-3-(R)-yl ester

생성물 1

HCID 67321078
4-[[2-carboxy-5-(3,3-dimethyl-but-1-ynyl)-thiophen-3-yl]-(4-methyl-cyclohexanecarbonyl)-amino]-piperidine-1-carboxylic acid hexahydro-furo[2,3-b]furan-3-(R)-yl ester

실험 절차

4-[[2-carboxy-5-(3,3-dimethyl-but-1-ynyl)-thiophen-3-yl]-(4-methyl-cyclohexanecarbonyl)-amino]-piperidine-1-carboxylic acid hexahydro-furo[2,3-b]furan-3-(R)-yl ester was prepared in a similar fashion to 5-(3,3-dimethyl-but-1-ynyl)-3-{(4-trans-methyl-cyclohexanecarbonyl)-[4-(tetrahydro-pyran-4-yloxycarbonylamino)-cyclohexyl]-amino}-thiophene-2-carboxylic acid using method B, except the HCl salt of 5-(3,3-dimethyl-but-1-ynyl)-3-[(4-methyl-cyclohexanecarbonyl)-piperidin-4-yl-amino]-thiophene-2-carboxylic acid methyl ester was used instead of 3-[(4-amino-cyclohexyl)-(4-trans-methyl-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid methyl ester, and 4-nitro-benzoic acid hexahydro-furo[2,3-b]furan-3-(R)-yl ester was used in place of the chloroformate of tetrahydro-pyran-4-ol.

출처 및 근거

ORD 기록
ord-ce1c7a69ef4b42b9b57f135327024620
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08524764B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트