Hydrogen Bromide → Phenol, 4-(5-octyl-2-pyridinyl)-

HRID 3931노트

반응식

HRID 3931 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][N:10]=2)=[CH:5][CH:4]=1.Br.O>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[CH:11][N:10]=2)=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 962WaterHCID 140699212-(4-Methoxyphenyl)-5-octylpyridine

생성물 1

HCID 1725484Phenol, 4-(5-octyl-2-pyridinyl)-

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The 2-(p-methoxyphenyl)-5-octylpyridine was dissolved in 100 ml of acetic acid. 8 ml of 48% hydrobromic acid was added to the reaction solution and the solution was heated for 15 hours under reflux. 100 ml of water was added to the reaction solution and the organic layer was extracted with chloroform. After washing the extract three times with water, the chloroform was removed by distillation. The residue was recrystallized from a mixture of acetone and hexane to yield 8.3 g (0.029 mol) of 2-(p-hydroxyphenyl)-5-octylpyridine.

후처리

  1. temperaturethe solution was heated for 15 hours
  2. temperatureunder reflux
  3. extractionthe organic layer was extracted with chloroform
  4. washAfter washing the
  5. extractionextract three times with water
  6. customthe chloroform was removed by distillation
  7. customThe residue was recrystallized from a mixture of acetone and hexane

출처 및 근거

ORD 기록
ord-af619c8be0ee4e34923575da7dc53150
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723018

반응 노트

불러오는 중…