Hydrochloric Acid → Ethyl 3-(4-hydroxy-3-methylphenyl)-5-isoxazolecarboxylate

HRID 393272노트

반응식

HRID 393272 반응식
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[O:13][N:12]=2)=[CH:7][C:6]=1[CH3:21].Cl>C1COCC1.CCOC(C)=O>[OH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:15]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[O:13][N:12]=2)=[CH:7][C:6]=1[CH3:21]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 22648868Ethyl 3-[4-(methoxymethoxy)-3-methyl phenyl]-5-isoxazolecarboxylate

생성물 1

HCID 136368683Ethyl 3-(4-hydroxy-3-methylphenyl)-5-isoxazolecarboxylate수율 70.5%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of ethyl 3-[4-(methoxymethoxy)-3-methylphenyl]-5-isoxazolecarboxylate (725 mg, 2.49 mmol) and aqueous 4 N HCl solution (6 mL) in THF (10 mL) was stirred at 25° C. for 16 h. The reaction mixture was diluted with EtOAc and successively washed with water and brine, dried (MgSO4), filtered and concentrated under reduced pressure to give the title compound (434 mg, 70% yield) as a yellow solid.

후처리

  1. washsuccessively washed with water and brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6022e58c5aa04eae9a3251c8514a04a2
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06806265B2

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