Formamide → HCID 22648863, 화합물

HRID 393287노트

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HRID 393287 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH3:12])[CH:6]=1)=O.[CH:13]([NH2:15])=[O:14]>>[O:14]1[CH:2]=[C:3]([C:5]2[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH3:12])[CH:6]=2)[N:15]=[CH:13]1

참가 물질

3

반응물 2

HCID 713FormamideHCID 112184492-Bromo-1-(4-hydroxy-3-methylphenyl)ethanone

생성물 1

HCID 22648863HCID 22648863, 화합물수율 33%

실험 절차

A solution of 2-bromo-1-(4-hydroxy-3-methylphenyl)ethanone (200 mg, 0.87 mmol) in formamide (10 mL) was heated to 110° C. for 24 h. The excess formamide was removed by distillation under reduced pressure. The resulting residue was partitioned between a pH 7.0 buffer solution (10 mL) and EtOAc (50 mL). The organic layer was washed with water (10 mL) and brine (10 mL), dried (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (Hexane:EtOAc, 1:1) to yield the title compound (51 mg, 33% yield).

후처리

  1. customThe excess formamide was removed by distillation under reduced pressure
  2. customThe resulting residue was partitioned between a pH 7.0 buffer solution (10 mL) and EtOAc (50 mL)
  3. washThe organic layer was washed with water (10 mL) and brine (10 mL)
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by flash chromatography (Hexane:EtOAc, 1:1)

출처 및 근거

ORD 기록
ord-f61df3abbbf64cc7a48e7f723b7b5a9d
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06806265B2

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