5-Benzyloxy-alpha,alpha,alpha',alpha'tetramethyl-1,3-benzenedimethanol → 3,5-Bis(1-methylethyl)phenol

HRID 393404

반응식

HRID 393404 반응식
C([O:8][C:9]1[CH:10]=[C:11]([C:19]([CH3:22])([CH3:21])O)[CH:12]=[C:13]([C:15]([CH3:18])([CH3:17])O)[CH:14]=1)C1C=CC=CC=1>C(O)C.Cl.[C].[Pd]>[CH:15]([C:13]1[CH:14]=[C:9]([OH:8])[CH:10]=[C:11]([CH:19]([CH3:22])[CH3:21])[CH:12]=1)([CH3:18])[CH3:17]

참가 물질

5

반응물 1

HCID 99223705-Benzyloxy-alpha,alpha,alpha',alpha'tetramethyl-1,3-benzenedimethanol

생성물 1

HCID 931043,5-Bis(1-methylethyl)phenol수율 100.4%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

To a solution of 5-benzyloxy-α,α,α′,α′-tetramethyl-1,3-benzenedimethanol (22.9 g, 76 mmol) in ethanol (500 mL), concentrated hydrochloric acid (2.6 mL) and a 10% palladium-carbon catalyst (8.0 g) were added. Under hydrogen atmosphere, the mixture was stirred for 23 hours at 60° C. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure, to thereby yield 13.6 g of 3,5-diisopropylphenol as a solid (yield 100%). The solid was crystallized from hexane, to thereby yield colorless needles.

후처리

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-8d6cd646ce274afb8122d80d40d75890
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06806395B2

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