2,2'-(5-Hydroxy-1,3-phenylene)bis(propan-2-ol) → 3,5-Bis(1-methylethyl)phenol

HRID 393405

반응식

HRID 393405 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:12]([CH3:15])([CH3:14])O)[CH:5]=[C:6]([C:8]([CH3:11])([CH3:10])O)[CH:7]=1>C(O)C.Cl.[C].[Pd]>[CH:8]([C:6]1[CH:7]=[C:2]([OH:1])[CH:3]=[C:4]([CH:12]([CH3:15])[CH3:14])[CH:5]=1)([CH3:11])[CH3:10]

참가 물질

5

반응물 1

HCID 226603332,2'-(5-Hydroxy-1,3-phenylene)bis(propan-2-ol)

생성물 1

HCID 931043,5-Bis(1-methylethyl)phenol수율 97.3%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

To a solution of 5-hydroxy-α,α,α′,α′-tetramethyl-1,3-benzenedimethanol (20.0 g, 95.1 mmol) in ethanol (600 mL), concentrated hydrochloric acid (12.0 mL) and a 10% palladium-carbon catalyst (11.0 g) were added, and the mixture was stirred under hydrogen atmosphere for 22 hours at room temperature. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure, to thereby yield a white solid. The thus-obtained solid was crystallized from hexane, to thereby yield 16.5 g of 3,5-diisopropylphenol as colorless needles (yield 97.3%).

후처리

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customto thereby yield a white solid
  4. customThe thus-obtained solid was crystallized from hexane

출처 및 근거

ORD 기록
ord-72d8ee25c369452891b9524d80abc868
출처 데이터셋
uspto-grants-2004_10
특허 번호
US06806395B2

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