Diisopropylethylamine → 4-[[(4-cyano-4-phenyl-1-piperidinyl)carbonyl]amino]-N-[(2,2-dichloro-1-methylcyclopropyl)carbonyl]-L-phenylalanine

A suspension of 4-[[(4-cyano-4-phenyl-1-piperidinyl)carbonyl]amino]-L-phenylalanine on Wang resin (0.30 g, 0.228 mmol), 2,2-dichloro-1-methylcyclopropane carboxylic acid (0.19 g, 1.14 mmol), BOP (0.50 g, 1.14 mmol) and DIPEA (0.26 mL, 1.5 mmol) in N-methylpyrrolidinone (3 mL) was agitated for 3 hr. The mixture was filtered and washed with dichloromethane and methanol. Cleavage from the resin was effected by treatment with 90% TFA in dichloromethane for 3 min. The mixture was filtered and the filtrate evaporated to give 4-[[(4-cyano-4-phenyl-1-piperidinyl)carbonyl]amino]-N-[(2,2-dichloro-1-methylcyclopropyl)carbonyl]-L-phenylalanine. FAB MS m/z 543 (M+H).

1. filtrationThe mixture was filtered
2. washwashed with dichloromethane and methanol
3. waitCleavage from the resin was effected by treatment with 90% TFA in dichloromethane for 3 min
4. filtrationThe mixture was filtered
5. customthe filtrate evaporated

ORD 기록

ord-f7012c36992b49ada743a4b148da1dc5

출처 데이터셋

uspto-grants-2004_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US06806365B2